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1

Accelerating anticancer drug development — opportunities and trade-offs

Nass, Sharyl J., Rothenberg, Mace L., Pentz, Rebecca, Hricak, Hedvig, Abernethy, Amy, Anderson, Kenneth, Gee, Amanda Wagner, Harvey, R. Donald, Piantadosi, Steven, Bertagnolli, Monica M., Schrag, Debo

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2018

Language:

english

File:

PDF, 834 KB

english, 2018

2

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

Nelson, Amy R., Fingleton, Barbara, Rothenberg, Mace L., Matrisian, Lynn M.

Journal:

Journal of Clinical Oncology

Year:

2000

Language:

english

File:

PDF, 445 KB

english, 2000

3

An investigational new drug treatment program for patients with gemcitabine : Results for over 3000 patients with pancreatic carcinoma

Anna Maria Storniolo, Nathan H. Enas, Cheryl A. Brown, Maurizio Voi, Mace L. Rothenberg, Richard Schilsky

Journal:

Year:

1999

Language:

english

File:

PDF, 122 KB

english, 1999

4

Dual Blockade of the EGFR and COX-2 Pathways

Chan, Emily, LaFleur, Bonnie, Rothenberg, Mace L., Merchant, Nipun, Lockhart, Albert Craig, Trivedi, Bakula, Chung, Christine H., Coffey, Robert J., Berlin, Jordan D.

Journal:

American Journal of Clinical Oncology

Year:

2011

Language:

english

File:

PDF, 166 KB

english, 2011

5

Intraperitoneal Therapy for Stage III Ovarian Cancer: A Therapy Whose Time Has Come!

Alberts, David S., Markman, Maurie, Armstrong, Deborah, Rothenberg, Mace L., Muggia, Franco, Howell, Stephen B.

Journal:

Journal of Clinical Oncology

Year:

2002

Language:

english

File:

PDF, 25 KB

english, 2002

6

Analysis of Response Data for Assessing Treatment Effects in Comparative Clinical Studies

Huang, Bo, Tian, Lu, McCaw, Zachary R., Luo, Xiaodong, Talukder, Enayet, Rothenberg, Mace, Xie, Wanling, Choueiri, Toni K., Kim, Dae Hyun, Wei, Lee-Jen

Journal:

Annals of Internal Medicine

Year:

2020

File:

PDF, 159 KB

2020

7

A rationale for expanding the endpoints for clinical trials in advanced pancreatic carcinoma

Mace L. Rothenberg, James L. Abbruzzese, Malcolm Moore, Russell K. Portenoy, John M. Robertson, Harold J. Wanebo

Journal:

Year:

1996

Language:

english

File:

PDF, 689 KB

english, 1996

8

A rationale for expanding the endpoints for clinical trials in advanced pancreatic carcinoma

Mace L. Rothenberg, James L. Abbruzzese, Malcolm Moore, Russell K. Portenoy, John M. Robertson, Harold J. Wanebo

Journal:

Year:

1996

Language:

english

File:

PDF, 689 KB

english, 1996

9

Dose intensive combination platinum and cyclophosphamide in the treatment of patients with advanced untreated epithelial ovarian cancer

Jeremy D. Shapiro, Mace L. Rothenberg, Gisele A. Sarosy, Seth M. Steinberg, Debra O. Adamo, Eddie Reed, Robert F. Ozols, Elise C. Kohn

Journal:

Year:

1998

Language:

english

File:

PDF, 103 KB

english, 1998

10

A multicenter, Phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma

Mace L. Rothenberg, John V. Cox, Russell F. DeVore, John D. Hainsworth, Richard Pazdur, Saul E. Rivkin, John S. Macdonald, Charles E. Geyer Jr., John Sandbach, Daniel L. Wolf, J. Scott Mohrland, Gary

Journal:

Year:

1999

Language:

english

File:

PDF, 110 KB

english, 1999

11

PHARMACOKINETICS OF ELEMENTAL PLATINUM (ULTRAFILTRATE AND TOTAL) AFTER A THIRTY MINUTE INTRAVENOUS INFUSION OF ORMAPLATIN

WILLIAM D. FIGG, MICHAELE C. CHRISTIAN, RICHARD LUSH, CHARLES J. LINK, PATRICIA DAVIS, ELISE KOHN, GISELE SAROSY, MACE L. ROTHENBERG, RAYMOND B. WEISS, NATHAN RYAN, JOAN JACOBS, EDDIE REED

Journal:

Biopharmaceutics & Drug Disposition

Year:

1997

Language:

english

File:

PDF, 185 KB

english, 1997

12

Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma

Christine H. Chung, Paula R. Pohlmann, Mace L. Rothenberg, Brian B. Burkey, Joel Parker, Kevin Palka, Joseph Aulino, Igor Puzanov, Barbara Murphy

Journal:

Year:

2011

Language:

english

File:

PDF, 751 KB

english, 2011

13

Determination of chemically reduced pyrrolobenzodiazepine SJG-136 in human plasma by HPLC-MS/MS: application to an anticancer phase I dose escalation study

M. Wade Calcutt, Wooin Lee, Igor Puzanov, Mace L. Rothenberg, David L. Hachey

Journal:

Journal of Mass Spectrometry

Year:

2008

Language:

english

File:

PDF, 323 KB

english, 2008

14

New Drugs on the Horizon: Matrix Metalloproteinase Inhibitors

Dr. Mace L. Rothenberg, Amy R. Nelson, Kenneth R. Hande

Journal:

Year:

1999

Language:

english

File:

PDF, 37 KB

english, 1999

15

Multidrug resistance in cancer chemotherapy

Nomita H. Patel, Mace L. Rothenberg

Journal:

Investigational New Drugs

Year:

1994

Language:

english

File:

PDF, 1.21 MB

english, 1994

16

Safety and pharmacokinetic study of RPI.4610 (ANGIOZYME), an anti-VEGFR-1 ribozyme, in combination with carboplatin and paclitaxel in patients with advanced solid tumors

Hiroyuki Kobayashi, S. Gail Eckhardt, Jennifer A. Lockridge, Mace L. Rothenberg, Alan B. Sandler, Cindy L. O’Bryant, Wendy Cooper, Scott N. Holden, Roger D. Aitchison, Nassim Usman, Maurice Wolin, Mic

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 259 KB

english, 2005

17

A phase I trial of CEP-701 + gemcitabine in patients with advanced adenocarcinoma of the pancreas

Emily Chan, Daniel Mulkerin, Mace Rothenberg, Kyle D. Holen, A. Craig Lockhart, James Thomas, Jordan Berlin

Journal:

Investigational New Drugs

Year:

2008

Language:

english

File:

PDF, 120 KB

english, 2008

18

Phase I trial of pemetrexed plus oxaliplatin administered every other week in patients with metastatic cancer

Daniel G. Stover, A. Craig Lockhart, Jordan D. Berlin, Emily Chan, Alan B. Sandler, Jeffery A. Sosman, Victoria Middlebrook, Steven Nicol, Mace L. Rothenberg

Journal:

Investigational New Drugs

Year:

2008

Language:

english

File:

PDF, 149 KB

english, 2008

19

A phase I dose escalation study of TTI-237 in patients with advanced malignant solid tumors

Andrea Wang-Gillam, Susanne M. Arnold, Ronald M. Bukowski, Mace L. Rothenberg, Wendy Cooper, Kenneth K. Wang, Eric Gauthier, A. Craig Lockhart

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 186 KB

english, 2012

20

Phase I study of oral irinotecan as a single-agent and given sequentially with capecitabine

Laura W. Goff, Al B. Benson, Patricia M. LoRusso, Antoinette R. Tan, Jordan D. Berlin, Louis J. Denis, Rebecca J. Benner, Donghua Yin, Mace L. Rothenberg

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 188 KB

english, 2012

21

Chemotherapeutic advances in pancreatic cancer

Jordan D. Berlin, Mace L. Rothenberg

Journal:

Current Oncology Reports

Year:

2003

Language:

english

File:

PDF, 394 KB

english, 2003

22

p53 and p21 Are Major Cellular Determinants for DNA Topoisomerase I-Mediated Radiation Sensitization in Mammalian Cells

ALLAN Y. CHEN, PAUL B. SCRUGGS, LING GENG, MACE L. ROTHENBERG, DENNIS E. HALLAHAN

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 151 KB

english, 2000

23

Opinion: Improving the evaluation of new cancer treatments: challenges and opportunities

Rothenberg, Mace L., Carbone, David P., Johnson, David H.

Journal:

Nature Reviews Cancer

Year:

2003

Language:

english

File:

PDF, 226 KB

english, 2003

24

Phase II study of flutamide as second line chemotherapy in patients with advanced pancreatic cancer

Jivesh J. Sharma, Betty Razvillas, C.D. Stephens, Susan G. Hilsenbeck, Ashu Sharma, Mace L. Rothenberg

Journal:

Investigational New Drugs

Year:

1997

Language:

english

File:

PDF, 37 KB

english, 1997

25

A Phase I Study of Vitamin E, 5-Fluorouracil and Leucovorin for Advanced Malignancies

Charles D. Blanke, Michael Stipanov, Jason Morrow, Mace Rothenberg, Rebecca Chinery, Yu Shyr, Robert Coffey, David H. Johnson, Steven D. Leach, R. Daniel Beauchamp

Journal:

Investigational New Drugs

Year:

2001

Language:

english

File:

PDF, 83 KB

english, 2001

26

Phase II Trial of Oral Altretamine for Consolidation of Clinical Complete Remission in Women with Stage III Epithelial Ovarian Cancer: A Southwest Oncology Group Trial (SWOG-9326)

Mace L. Rothenberg, P.Y. Liu, Sharon Wilczynski, Edward V. Hannigan, Sheldon A. Weiner, Geoffrey R. Weiss, Verda J. Hunter, Julia A. Chapman, Amy Tiersten, Peter C. Kohler, David S. Alberts

Journal:

Gynecologic Oncology

Year:

2001

Language:

english

File:

PDF, 61 KB

english, 2001

27

Gastric and Esophageal Cancers: Perspectives from a U.S.-Japan Meeting

Mace L. Rothenberg, Masanori Fukushima, Charles A. Coltman

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1994

Language:

english

File:

PDF, 846 KB

english, 1994

28

Summary of a joint meeting between the Southwest Oncology Group and the Japanese Clinical Trials Consortium

Mace L. Rothenberg, Charles A. Coltman, Masanori Fukushima

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1993

Language:

english

File:

PDF, 482 KB

english, 1993

29

14A A design for assessing clinical benefit for patients with advanced pancreatic cancer

John S. Andersen, Howard Burris, Ephraim Casper, Michael Clayman, Mark Green, Robert L. Nelson, Russell Portenoy, Mace Rothenberg, Peter G. Tarassoff, Daniel Von Hoff

Journal:

Controlled Clinical Trials

Year:

1994

Language:

english

File:

PDF, 54 KB

english, 1994

30

Phase II trial of vinorelbine for relapsed ovarian cancer: a Southwest Oncology Group study

Mace L. Rothenberg, P.Y. Liu, Sharon Wilczynski, William A. Nahhas, Gaye L. Winakur, Caroline S. Jiang, Carol M. Moinpour, Ben Lyons, Geoffrey R. Weiss, James H. Essell, Harriet O. Smith, Maurie Markm

Journal:

Gynecologic Oncology

Year:

2004

Language:

english

File:

PDF, 242 KB

english, 2004

31

Analysis of neurosensory adverse events induced by FOLFOX4 treatment in colorectal cancer patients: a comparison between two Asian studies and four Western studies

Kenichi Sugihara, Atsushi Ohtsu, Yasuhiro Shimada, Nobuyuki Mizunuma, Katsushige Gomi, Po-Huang Lee, Aimery de Gramont, Mace L. Rothenberg, Thierry André, Silvano Brienza, Richard M. Goldberg

Journal:

Cancer Medicine

Year:

2012

Language:

english

File:

PDF, 1.52 MB

english, 2012

32

Safety Analysis of FOLFOX4 Treatment in Colorectal Cancer Patients: A Comparison Between Two Asian Studies and Four Western Studies

Kenichi Sugihara, Atsushi Ohtsu, Yasuhiro Shimada, Nobuyuki Mizunuma, Po-Huang Lee, Aimery de Gramont, Richard M. Goldberg, Mace L. Rothenberg, Thierry André, Silvano Brienza, Katsushige Gomi

Journal:

Clinical Colorectal Cancer

Year:

2012

Language:

english

File:

PDF, 574 KB

english, 2012

33

A phase I study of subcutaneously administered aflibercept (VEGF trap) in a new formulation in patients with advanced solid tumors

Andrea Wang-Gillam, William P. Tew, Mace L. Rothenberg, Jakob Dupont, Wendy Cooper, Lars Sternas, Giliane Buzenet, Jeffrey A. Sosman, David R. Spriggs, Albert Craig Lockhart

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 127 KB

english, 2012

34

A phase I study of concurrent 9-nitro-20(s)-camptothecin (9NC/Orathecin) and radiation therapy in the treatment of locally advanced adenocarcinoma of the pancreas

Karen L. Tedesco, Jordan Berlin, Mace Rothenberg, Hak Choy, Ken Wyman, Adrian Scott Pearson, Robert Daniel Beauchamp, Nipun Merchant, A. Craig Lockhart, Yu Shyr, Carol Caillouette, Bapsi Chakravarthy

Journal:

Radiotherapy and Oncology

Year:

2005

Language:

english

File:

PDF, 85 KB

english, 2005

35

Capecitabine Combinations in the Treatment of Advanced Colorectal Cancer

Maxine D. Fisher, Mace L. Rothenberg, Edward Chu

Journal:

Clinical Colorectal Cancer

Year:

2001

Language:

english

File:

PDF, 89 KB

english, 2001

36

Oxaliplatin Combinations as First-Line Therapy in Advanced Colorectal Cancer

Kavita Maung, Edward Chu, Mace Rothenberg

Journal:

Clinical Colorectal Cancer

Year:

2002

Language:

english

File:

PDF, 96 KB

english, 2002

37

Treatment for Pancreatic Cancer: Current Therapy and Continued Progress

A. Craig Lockhart, Mace L. Rothenberg, Jordan D. Berlin

Journal:

Gastroenterology

Year:

2005

Language:

english

File:

PDF, 304 KB

english, 2005

38

The Current Status of Irinotecan (CPT-11) in the United States

MACE L. ROTHENBERG

Journal:

Annals of the New York Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 586 KB

english, 1996

39

Current Approaches to First-Line Treatment of Advanced Colorectal Cancer

Mace L. Rothenberg

Journal:

Clinical Colorectal Cancer

Year:

2004

Language:

english

File:

PDF, 166 KB

english, 2004

40

Phase III Trial of FOLFOX plus Bevacizumab or Cediranib (AZD2171) as First-Line Treatment of Patients with Metastatic Colorectal Cancer: HORIZON III

Jane D. Robertson, Nick A. Botwood, Mace L. Rothenberg, Hans-Joachim Schmoll

Journal:

Clinical Colorectal Cancer

Year:

2009

Language:

english

File:

PDF, 77 KB

english, 2009

41

Phase II Trial of T138067, a Novel Microtubule Inhibitor, in Patients with Metastatic, Refractory Colorectal Carcinoma

Jordan D. Berlin, Alan Venook, Emily Bergsland, Mace Rothenberg, A. Craig Lockhart, Lee Rosen

Journal:

Clinical Colorectal Cancer

Year:

2008

Language:

english

File:

PDF, 87 KB

english, 2008

42

Population pharmacokinetics of PEGylated liposomal CPT-11 (IHL-305) in patients with advanced solid tumors

Wu, Huali, Infante, Jeffrey R., Keedy, Vicki L., Jones, Suzanne F., Chan, Emily, Bendell, Johanna C., Lee, Wooin, Zamboni, Beth A., Ikeda, Satoshi, Kodaira, Hiroshi, Rothenberg, Mace L., Burris, Howar

Journal:

European Journal of Clinical Pharmacology

Year:

2013

Language:

english

File:

PDF, 334 KB

english, 2013

43

TGF-β signalling-related markers in cancer patients with bone metastasis

Baselga, Jose, Rothenberg, Mace L., Tabernero, Josep, Seoane, Joan, Daly, Thomas, Cleverly, Ann, Berry, Brandi, Rhoades, Susanne K., Ray, Chad A., Fill, Jeffrey, Farrington, Daphne L., Anne Wallace, L

Journal:

Year:

2008

Language:

english

File:

PDF, 271 KB

english, 2008

44

Oncology

Rothenberg, Mace

Journal:

JAMA The Journal of the American Medical Association

Year:

1990

Language:

english

File:

PDF, 707 KB

english, 1990

45

Late Recurrent Candida Endocarditis

Johnston, Putrick G., Lee, James, Domunski, Michael, Dressler, Fred, Tucker, Eben, Rothenberg, Mace, Cunnion, Robert E., Pizzo, Philip A., Walsh, Thomas J.

Journal:

Year:

1991

Language:

english

File:

PDF, 2.02 MB

english, 1991

46

AOJ-1Asia as a center for global oncology drug development

Rothenberg, Mace L.

Journal:

Annals of Oncology

Year:

2015

Language:

english

File:

PDF, 24 KB

english, 2015

47

Phase I/Pilot Study of SU5416 (Semaxinib) in Combination With Irinotecan/Bolus 5-FU/LV (IFL) in Patients With Metastatic Colorectal Cancer

Lockhart, Albert Craig, Cropp, Gillian F., Berlin, Jordan D., Donnelly, Edwin, Schumaker, Robert D., Schaaf, Larry J., Hande, Kenneth R., Fleischer, Arthur C., Hannah, Alison L., Rothenberg, Mace L.

Journal:

American Journal of Clinical Oncology

Year:

2006

Language:

english

File:

PDF, 364 KB

english, 2006

48

Activity of CPT-11 (irinotecan hydrochloride), a topoisomerase I inhibitor, against human tumor colony-forming units

Shimada, Yasuhiro, Rothenberg, Mace, Hilsenbeck, Susan G, Burris, Howard A, Degen, Donna, Von Hoff, Daniel D

Journal:

Anti-Cancer Drugs

Year:

1994

File:

PDF, 343 KB

1994

49

The clinical development of new mitotic inhibitors that stabilize the microtubule

Mani, Sridhar, Macapinlac, Manuel, Goel, Sanjay, Verdier-Pinard, Dominik, Fojo, Tito, Rothenberg, Mace, Colevas, Dimitrios

Journal:

Anti-Cancer Drugs

Year:

2004

Language:

english

File:

PDF, 132 KB

english, 2004

50

A Phase I Dose-Escalation Study of SR271425, an Intravenously Dosed Thioxanthone Analog, Administered Weekly in Patients With Refractory Solid Tumors

Lockhart, A Craig, Calvo, Emiliano, Tolcher, Anthony W., Rowinsky, Eric K., Shackleton, Gareth, Morrison, J Gilmour, Rafi, Rezvan, VerMeulen, Wendy, Rothenberg, Mace L.

Journal:

American Journal of Clinical Oncology

Year:

2009

Language:

english

File:

PDF, 402 KB

english, 2009